Ndufb4 Gene Summary [Rat]
Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrial inner membrane. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufb4 |
| Official Name | NADH:ubiquinone oxidoreductase subunit B4 [Source:RGD Symbol;Acc:1307072] |
| Ensembl ID | ENSRNOG00000002721 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit B4 |
| Synonyms | 0610006N12Rik, 1300010H20Rik, B15, CI-B15, Complex I-B15, LOC727762, NADH:ubiquinone oxidoreductase subunit B4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
- NADH2 dehydrogenase
- enzyme
- NADH2 dehydrogenase (ubiquinone)
Pathways
Biological processes and signaling networks where the Ndufb4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- non-small cell lung carcinoma
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- Huntington disease
- insulin resistance
regulates
- docetaxel
role in cell
- autophagy in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrion
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NADH dehydrogenase (ubiquinone) activity