Arhgap31 Gene Summary [Rat]
Predicted to enable GTPase activator activity and SH3 domain binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be active in lamellipodium. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and coronary artery disease. Orthologous to human ARHGAP31 (Rho GTPase activating protein 31). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap31 |
| Official Name | Rho GTPase activating protein 31 [Source:RGD Symbol;Acc:1306093] |
| Ensembl ID | ENSRNOG00000003088 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 31 |
| Synonyms | 5830477L08Rik, AOS, AOS1, CDGAP, D330026I07Rik, KIAA1204, Rho GTPase activating protein 31 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgap31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- polybasic region
- central domain
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- proline rich domain
- SH3-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- schizophrenia
- neoplasia
- acute myeloid leukemia
- metastasis
- systemic lupus erythematosus
- Adams-Oliver syndrome type 1
- autoimmune disease
- celiac disease
- organismal death
role in cell
- expression in
- activation in
- migration
- cell rounding
- inactivation in
- ruffling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgap31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytosol
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- SH3 domain binding