Qdpr Gene Summary [Rat]
Enables 6,7-dihydropteridine reductase activity; adenyl nucleotide binding activity; and identical protein binding activity. Involved in several processes, including L-phenylalanine catabolic process; response to glucagon; and tetrahydrobiopterin biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Biomarker of hypertension and status epilepticus. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia C and phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Qdpr |
| Official Name | quinoid dihydropteridine reductase [Source:RGD Symbol;Acc:619915] |
| Ensembl ID | ENSRNOG00000003253 |
| Bio databases IDs | |
| Aliases | quinoid dihydropteridine reductase |
| Synonyms | 2610008L04Rik, D5Ertd371e, DHPR, HDHPR, PKU2, quinoid dihydropteridine reductase, SDR33C1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Qdpr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- NAD or NADH binding
- NADPH binding
- electron carrier
- binding protein
- dihydropteridine reductase
- enzyme
- short chain dehydrogenase
- identical protein binding
Pathways
Biological processes and signaling networks where the Qdpr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon adenocarcinoma
- colon epithelial cancer
- atypical phenylketonuria
- azoxymethane/dextran sodium sulfate induced colorectal cancer
- hyperphenylalaninemia
- 6-Pyruvoyl-tetrahydrobiopterin synthase deficiency
regulates
- sapropterin
- homocysteine
- amino acids
- 5,10-methenyltetrahydrofolate
- neopterin
- 7,8-dihydrobiopterin
- 10-formyltetrahydrofolic acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- synaptic vesicles
- transverse tubules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Qdpr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- L-phenylalanine catabolic process
- dihydrobiopterin metabolic process
- tetrahydrobiopterin biosynthetic process
- cellular amino acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- electron carrier activity
- NADPH binding
- 6,7-dihydropteridine reductase activity
- NADH binding