Vars1 Gene Summary [Rat]
Enables valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Orthologous to human VARS1 (valyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vars1 |
| Official Name | valyl-tRNA synthetase 1 [Source:RGD Symbol;Acc:3950] |
| Ensembl ID | ENSRNOG00000000867 |
| Bio databases IDs | |
| Aliases | valyl-tRNA synthetase 1 |
| Synonyms | Bat6, D17H6S56E, G7A, NDMSCA, tRNA-valine synthetase, TrsVal, VALRS, Valyl-tRNA synthetase, valyl-tRNA synthetase 1, VARS, VARS2, Vrs, V-tRNA ligase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vars1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Leucyl-tRNA synthetase, Domain 2
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- enzyme
- protein binding
- valyl-tRNA synthetase
- tRNA synthetases class I (I, L, M and V)
- class Ia aminoacyl tRNA synthetases anticodon binding domain
- leucyl-tRNA synthetase, eubacterial and mitochondrial family
- valine-tRNA ligase
- Anticodon-binding domain of tRNA ligase
- Valyl tRNA synthetase tRNA binding arm
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- neoplasia
- chronic interstitial cystitis
- inguinal hernia
- neurodevelopmental disorder with microcephaly, seizures and cortical atrophy
- sarcoidosis
- cutaneous melanoma
- cutaneous melanoma cancer
- ocular hypertension
role in cell
- expression in
- activation in
- molecular cleavage in
- vemurafenib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vars1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA aminoacylation for protein translation
- valyl-tRNA aminoacylation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- valine-tRNA ligase activity
- ATP binding
- protein binding
- aminoacyl-tRNA editing activity