Kmo Gene Summary [Rat]
Enables kynurenine 3-monooxygenase activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to lipopolysaccharide; and positive regulation of glutamate secretion, neurotransmission. Located in extracellular space and mitochondrial outer membrane. Used to study schizophrenia. Biomarker of depressive disorder. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kmo |
| Official Name | kynurenine 3-monooxygenase [Source:RGD Symbol;Acc:620610] |
| Ensembl ID | ENSRNOG00000003709 |
| Bio databases IDs | |
| Aliases | kynurenine 3-monooxygenase |
| Synonyms | dJ317G22.1, Kynurenine 3-hydroxylase, Kynurenine 3-monooxygenase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kmo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- FAD binding
- Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family
- FAD binding domain
- flavin adenine dinucleotide binding
- kynurenine 3-monooxygenase
- NADPH oxidase
- enzyme
- protein binding
- ubiquinone biosynthesis monooxygenase COQ6
Pathways
Biological processes and signaling networks where the Kmo gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- insulin-dependent diabetes mellitus
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- myocardial infarction
- liver cancer
- hepatocellular carcinoma
- adult T-cell leukemia/lymphoma
- hepatic injury
- autoimmune metaplastic atrophic gastritis
role in cell
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kmo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- quinolinate biosynthetic process
- tryptophan catabolic process
- response to salt stress
- cellular response to lipopolysaccharide
- de novo NAD biosynthetic process from tryptophan
- kynurenic acid biosynthetic process
- kynurenine metabolic process
- NAD metabolic process
- cellular response to interleukin-1
- anthranilate metabolic process
- L-kynurenine metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- FAD binding
- kynurenine 3-monooxygenase activity
- flavin adenine dinucleotide binding
- NAD(P)H oxidase activity