Tmem163 Gene Summary [Rat]
Enables zinc ion binding activity. Involved in zinc ion import into synaptic vesicle. Located in early endosome membrane. Is active in synaptic vesicle membrane. Used to study proteinuria. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 25. Orthologous to human TMEM163 (transmembrane protein 163). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem163 |
| Official Name | transmembrane protein 163 [Source:RGD Symbol;Acc:1306212] |
| Ensembl ID | ENSRNOG00000003769 |
| Bio databases IDs | |
| Aliases | transmembrane protein 163 |
| Synonyms | 2610024A01Rik, A-cre, Act-Cre, actin-cre, cre<actin>, DC29, HLD25, RGD1306212, SLC30A11, SV31, Tg(ACTB-cre)2Mrt, transmembrane protein 163 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmem163 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- protein binding
- Cation efflux family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- Parkinson disease
- hypomyelinating leukodystrophy type 25
- hermansky-pudlak syndrome type 3
- kidney carcinoma
- renal cancer
- primary biliary cirrhosis
- Alzheimer disease
- asthma
regulates
- Zn2+
role in cell
- accumulation in
- myelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- intracellular membrane-bounded organelle
- Plasma Membrane
- vesicles
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmem163 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myelination
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- synaptic vesicle membrane
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding