Tmem163 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Predicted to be involved in myelination; zinc export across plasma membrane; and zinc ion import into synaptic vesicle. Located in synaptic vesicle membrane. Is active in intracellular vesicle and plasma membrane. Is expressed in cerebral cortex; cortical layer V; cortical subplate; heart; and limb. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 25. Orthologous to human TMEM163 (transmembrane protein 163). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tmem163 |
| Official Name | transmembrane protein 163 [Source:MGI Symbol;Acc:MGI:1919410] |
| Ensembl ID | ENSMUSG00000026347 |
| Bio databases IDs | |
| Aliases | transmembrane protein 163 |
| Synonyms | 2610024A01Rik, A-cre, Act-Cre, actin-cre, cre<actin>, DC29, HLD25, RGD1306212, SLC30A11, SV31, Tg(ACTB-cre)2Mrt, transmembrane protein 163 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem163 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- protein binding
- Cation efflux family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- Parkinson disease
- hypomyelinating leukodystrophy type 25
- hermansky-pudlak syndrome type 3
- kidney carcinoma
- renal cancer
- primary biliary cirrhosis
- Alzheimer disease
- asthma
regulates
- Zn2+
role in cell
- accumulation in
- myelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- intracellular membrane-bounded organelle
- Plasma Membrane
- vesicles
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem163 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myelination
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- synaptic vesicle membrane
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding