Ap3s1 Gene Summary [Rat]
Predicted to be involved in anterograde synaptic vesicle transport and vesicle-mediated transport. Is active in synaptic vesicle. Orthologous to human AP3S1 (adaptor related protein complex 3 subunit sigma 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap3s1 |
| Official Name | adaptor related protein complex 3 subunit sigma 1 [Source:RGD Symbol;Acc:1311115] |
| Ensembl ID | ENSRNOG00000003829 |
| Bio databases IDs | |
| Aliases | adaptor related protein complex 3 subunit sigma 1 |
| Synonyms | adaptor-related protein complex 3, sigma 1 subunit, adaptor related protein complex 3 subunit sigma 1, adaptor related protein complex 3 subunit σ 1, adaptor-related protein complex 3, σ 1 subunit, Ap3s1 predicted, CLAPS3, Sigma3A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ap3s1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Clathrin adaptor complex small chain
- APS2
- protein binding
- Longin-like domains
- transporter
Pathways
Biological processes and signaling networks where the Ap3s1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- trans Golgi network
- synaptic vesicles
- transport vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ap3s1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- platelet dense granule organization
- vesicle-mediated transport
- anterograde axon cargo transport
- insulin receptor signaling pathway
- synaptic vesicle coating
- intracellular transport
- intracellular protein transport
- cargo loading into clathrin-coated vesicle, AP-3-mediated
- anterograde synaptic vesicle transport
- Golgi to vacuole transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- early endosome
- AP-type membrane coat adaptor complex
- intracellular membrane-bounded organelle
- AP-3 adaptor complex
- Golgi apparatus
- transport vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding