Apln Gene Summary [Rat]
Enables apelin receptor binding activity and identical protein binding activity. Involved in several processes, including apelin receptor signaling pathway; positive regulation of peptide hormone secretion; and regulation of blood circulation. Located in extracellular space and perinuclear region of cytoplasm. Used to study congestive heart failure. Biomarker of colitis; congestive heart failure; hypertension; and obesity. Orthologous to human APLN (apelin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apln |
| Official Name | apelin [Source:RGD Symbol;Acc:620672] |
| Ensembl ID | ENSRNOG00000003984 |
| Bio databases IDs | |
| Aliases | apelin |
| Synonyms | 6030430G11Rik, APEL, Apelin, Preproapelin, XNPEP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Apln often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- APJ endogenous ligand
- G-protein-coupled receptor binding
- hormone
- receptor binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Apln gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- vaso-occlusion
- spontaneous hypertension
- chronic obstructive pulmonary disease
- pulmonary hypertension
- anophthalmia
- non-insulin-dependent diabetes mellitus
- heart disease
- organismal death
role in cell
- phosphorylation in
- expression in
- apoptosis
- activation in
- proliferation
- survival
- growth
- adhesion
- activation
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- vesicles
- cytoplasmic particles
- cytoplasmic vesicles
- perikaryon
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Apln gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- drinking behavior
- negative regulation of fibroblast growth factor receptor signaling pathway
- apelin receptor signaling pathway
- signal transduction
- coronary vasculature development
- negative regulation of blood pressure
- lactation
- positive regulation of heart contraction
- gastrulation
- negative regulation of gene expression
- immune response
- angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- apelin receptor binding
- receptor binding
- hormone activity