Timp3 Gene Summary [Rat]
Predicted to enable metalloendopeptidase inhibitor activity and zinc ion binding activity. Involved in several processes, including cellular response to peptide; mesenchymal cell differentiation involved in bone development; and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix and extracellular space. Biomarker of sciatic neuropathy and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Timp3 |
| Official Name | TIMP metallopeptidase inhibitor 3 [Source:RGD Symbol;Acc:3865] |
| Ensembl ID | ENSRNOG00000004303 |
| Bio databases IDs | |
| Aliases | TIMP metallopeptidase inhibitor 3 |
| Synonyms | HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3, tissue inhibitor of metalloproteinase 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Timp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- zinc ion binding
- protein binding
- metalloendopeptidase inhibitor
- Tissue inhibitor of metalloproteinase
Pathways
Biological processes and signaling networks where the Timp3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- squamous cell cancer of the oral cavity
- asthma
- prostate cancer
- breast cancer
- colon cancer
- lung adenocarcinoma
- pancreatic epithelial cancer
- heart failure
role in cell
- growth
- quantity
- morphology
- cell death
- expression in
- degradation in
- phosphorylation in
- cellular infiltration by
- proliferation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- cell surface
- basal compartment
- extracellular matrix
- perikaryon
- dendrites
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Timp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- negative regulation of membrane protein ectodomain proteolysis
- negative regulation of endopeptidase activity
- response to hormone stimulus
- visual perception
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- basement membrane
- platelet dense granule lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- protease binding
- metalloendopeptidase inhibitor activity