Ca9 Gene Summary [Rat]
Predicted to enable carbonate dehydratase activity; molecular function activator activity; and zinc ion binding activity. Involved in response to hypoxia; response to testosterone; and response to xenobiotic stimulus. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hepatitis B; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human CA9 (carbonic anhydrase 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ca9 |
| Official Name | carbonic anhydrase 9 [Source:RGD Symbol;Acc:1306426] |
| Ensembl ID | ENSRNOG00000017073 |
| Bio databases IDs | |
| Aliases | carbonic anhydrase 9 |
| Synonyms | CA IX, Car9, carbonic anhydrase 9, MN, MN/CA9, renal cell carcinoma-associated antigen G250 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ca9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- carbonate dehydratase
- Eukaryotic-type carbonic anhydrase
- intracellular domain
- alpha_CA
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- vomiting
- edema
- hepatocellular carcinoma
- neoplasia
- hypertension
- depressive disorder
- epilepsy
- non-insulin-dependent diabetes mellitus
- alcoholism
- heart failure
role in cell
- expression in
- activation in
- survival
- proliferation
- downregulation in
- production in
- migration
- growth
- number
- pH
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intracellular space
- cellular membrane
- Plasma Membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ca9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- secretion
- response to hypoxia
- morphogenesis of an epithelium
- response to testosterone stimulus
- response to xenobiotic stimulus
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- membrane
- nucleolus
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- carbonate dehydratase activity