Bdkrb2 Gene Summary [Rat]
Enables beta-2 adrenergic receptor binding activity and bradykinin receptor activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; cellular response to hypoxia; and maintenance of blood-brain barrier. Predicted to be located in endosome. Predicted to be active in plasma membrane. Used to study several diseases, including asthma; pancreatitis; pleurisy; portal hypertension; and pulmonary hypertension. Biomarker of high grade glioma; hypertension; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bdkrb2 |
| Official Name | bradykinin receptor B2 [Source:RGD Symbol;Acc:2201] |
| Ensembl ID | ENSRNOG00000047300 |
| Bio databases IDs | |
| Aliases | bradykinin receptor B2 |
| Synonyms | B2, B(2), B2BKR, B2BRA, B2R, B2 receptor, BK-2, BK2R, Bkb2, BKR2, BRADYKININ B2 receptor, bradykinin receptor B2, bradykinin receptor, beta 2, bradykinin receptor, β 2, BRB2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bdkrb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Cholecystokinin A receptor, N-terminal
- protease binding
- G-protein-coupled receptor binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- immunoreceptor tyrosine-based inhibition motif
- transmembrane domain
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
- bradykinin receptor
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Bdkrb2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- cancer
- albuminuria
- neoplasia
- fibrosis
- shock response
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- diffuse mesangial sclerosis
- prostate cancer
role in cell
- migration
- apoptosis
- phosphorylation in
- proliferation
- production in
- chemotaxis
- activation in
- inhibition in
- formation
- sprouting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cell borders
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- Golgi Apparatus
- cytoplasmic aggregates
- membrane rafts
- cell membrane leading edge
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bdkrb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to salt stress
- G-protein coupled receptor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- blood circulation
- regulation of vascular permeability
- vasoconstriction
- cell surface receptor signaling pathway
- vasodilation
- elevation of cytosolic calcium ion concentration
- inflammatory response
- arachidonic acid secretion
- smooth muscle contraction
- negative regulation of peptidyl-serine phosphorylation
- regulation of vasoconstriction
Cellular Component
Where in the cell the gene product is active
- endosome
- intracellular membrane-bounded organelle
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- type 1 angiotensin receptor binding
- protein heterodimerization activity
- bradykinin receptor activity
- protease binding