BDKRB1 Gene Summary [Human]
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | BDKRB1 |
| Official Name | bradykinin receptor B1 [Source:HGNC Symbol;Acc:HGNC:1029] |
| Ensembl ID | ENSG00000100739 |
| Bio databases IDs | |
| Aliases | bradykinin receptor B1 |
| Synonyms | B1BKR, B1R, Bdkrb, BKB1R, BKR, BKR1, BRADYB1, Bradykinin b1 receptor, bradykinin receptor B1, bradykinin receptor, beta 1, bradykinin receptor, β 1, KININ B1 receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BDKRB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- peptide binding
- Cholecystokinin A receptor, N-terminal
- transmembrane domain
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- bradykinin receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the BDKRB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- cognitive impairment
- hypoalgesia
- glomerulosclerosis
- endotoxin shock response
- neuroinflammation
- renal fibrosis
- renal impairment
- keratocystic odontogenic tumor
role in cell
- activation in
- apoptosis
- growth
- adhesion
- production in
- signaling in
- migration
- emigration
- invasiveness
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BDKRB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- negative regulation of blood pressure
- positive regulation of release of sequestered calcium ion into cytosol
- protein kinase C-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
- response to mechanical stimulus
- positive regulation of leukocyte migration
- inflammatory response
- negative regulation of cell growth
- negative regulation of protein phosphorylation
- response to lipopolysaccharide
- cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- bradykinin receptor activity
- peptide binding