Kng1 Gene Summary [Rat]
Predicted to enable cysteine-type endopeptidase inhibitor activity and hormone activity. Predicted to be involved in several processes, including negative regulation of blood coagulation; negative regulation of proteolysis; and vasodilation. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Used to study abdominal aortic aneurysm. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kng1 |
| Official Name | kininogen 1 [Source:RGD Symbol;Acc:1359376] |
| Ensembl ID | ENSRNOG00000030387 |
| Bio databases IDs | |
| Aliases | kininogen 1 |
| Synonyms | BDK, BK, HAE6, KININOGEN, KININOGEN 1, KINKG, KINKH, KINT1G, KNG, Kng1l1, KNG2, Kngk |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kng1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kininogen light chain domain
- CY
- cysteine protease inhibitor activity
- protease binding
- factor XI binding domain
- hormone
- protein binding
- receptor binding
- kininostatin
Pathways
Biological processes and signaling networks where the Kng1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- pain
- heat hyperalgesia
- glioma formation
- cholangiocarcinoma cancer
- coronary artery disease
- memory deficits
- Alzheimer disease
- hereditary angioedema type VI
- thrombosis
role in cell
- apoptosis
- proliferation
- expression in
- activation in
- phosphorylation in
- synthesis in
- quantity
- production in
- migration
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- Plasma Membrane
- endoplasmic reticulum lumen
- alpha granules
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kng1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- signal transduction
- negative regulation of cell adhesion
- positive regulation of apoptotic process
- negative regulation of blood coagulation
- negative regulation of endopeptidase activity
- negative regulation of proteolysis
- vasodilation
- blood coagulation
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- cysteine-type endopeptidase inhibitor activity
- heparin binding
- receptor binding
- hormone activity