Lta4h Gene Summary [Rat]
Enables leukotriene-A4 hydrolase activity. Involved in several processes, including leukotriene metabolic process; response to zinc ion; and type I pneumocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Biomarker of adenocarcinoma; asthma; and squamous cell carcinoma. Orthologous to human LTA4H (leukotriene A4 hydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lta4h |
| Official Name | leukotriene A4 hydrolase [Source:RGD Symbol;Acc:1311333] |
| Ensembl ID | ENSRNOG00000004494 |
| Bio databases IDs | |
| Aliases | leukotriene A4 hydrolase |
| Synonyms | Leukotriene A4 Hydrolase, Lkha4, LTA4, LTA-4 hydrolase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lta4h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase family M1 domain
- epoxide hydrolase
- metalloexopeptidase
- peptidase
- Leukotriene A4 hydrolase, C-terminal
- enzyme
- protein binding
- Peptidase M1 N-terminal domain
- zinc ion binding
- leukotriene A-4 hydrolase/aminopeptidase
- aminopeptidase
- peptidase GluZincin family
- leukotriene-A4 hydrolase
Pathways
Biological processes and signaling networks where the Lta4h gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic fatty liver disease
- acute inflammation
- hypersensitivity reaction type I
- acute coronary syndrome
- severe acute respiratory syndrome
regulates
- leukotriene B4
- leukotriene
- leukotriene A4
- lipoxin A4
- 6-trans-8-cis-leukotriene B4
- peptide
role in cell
- accumulation in
- cellular infiltration by
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ficolin-1-rich granule lumen
- Extracellular Space
- organelle lumens
- cytosol
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lta4h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein metabolic process
- peptide catabolic process
- response to zinc ion
- leukotriene biosynthetic process
- Type I pneumocyte differentiation
- lipid metabolic process
- proteolysis
- response to peptide hormone stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- protein binding
- tripeptide aminopeptidase activity
- metalloaminopeptidase activity
- aminopeptidase activity
- leukotriene-A4 hydrolase activity
- peptidase activity
- epoxide hydrolase activity