Mat1a Gene Summary [Rat]
Enables several functions, including adenyl ribonucleotide binding activity; magnesium ion binding activity; and methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and protein-containing complex assembly. Located in nuclear matrix. Human ortholog(s) of this gene implicated in hypermethioninemia. Orthologous to human MAT1A (methionine adenosyltransferase 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mat1a |
| Official Name | methionine adenosyltransferase 1A [Source:RGD Symbol;Acc:3050] |
| Ensembl ID | ENSRNOG00000011351 |
| Bio databases IDs | |
| Aliases | methionine adenosyltransferase 1A |
| Synonyms | AdoMet, AdoMet synthetase, Ams, MAT, Mat1, MATA1, Mat iii, methionine adenosyltransferase 1A, SADE, SAMS, SAMS1, SAS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mat1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S-adenosylmethionine synthetase, central domain
- ADP binding
- S-adenosylmethionine synthetase, C-terminal domain
- ATP binding
- S-adenosylmethionine synthetase
- enzyme
- protein binding
- magnesium ion binding
- identical protein binding
- methionine adenosyltransferase
- S-adenosylmethionine synthetase, N-terminal domain
- amino acid binding
Pathways
Biological processes and signaling networks where the Mat1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- stroke
- deficiency of methionine adenosyltransferase
- hyperplasia
- liver cancer
- autosomal recessive methionine adenosyltransferase deficiency
- autosomal dominant methionine adenosyltransferase deficiency
- steatohepatitis
- hepatocellular carcinoma
regulated by
- dexamethasone
- SMPD1
- triamcinolone
- GSK2816126
- decitabine
- hydrogen peroxide
- methotrexate
- actinomycin D
- BV02
- tazemetostat
role in cell
- expression in
- accumulation in
- cellular infiltration by
- trimethylation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mat1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- methionine catabolic process
- S-adenosylmethionine biosynthetic process
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- methionine adenosyltransferase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- metal ion binding
- methionine adenosyltransferase activity