Slc30a8 Gene Summary [Rat]
Enables zinc ion transmembrane transporter activity. Involved in several processes, including intracellular zinc ion homeostasis; positive regulation of insulin secretion; and zinc ion import across plasma membrane. Predicted to be located in secretory granule membrane. Predicted to be active in plasma membrane and secretory granule. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC30A8 (solute carrier family 30 member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc30a8 |
| Official Name | solute carrier family 30 member 8 [Source:RGD Symbol;Acc:1308282] |
| Ensembl ID | ENSRNOG00000004747 |
| Bio databases IDs | |
| Aliases | solute carrier family 30 member 8 |
| Synonyms | C820002P14RIK, solute carrier family 30 member 8, solute carrier family 30 (zinc transporter), member 8, ZNT8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc30a8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- cation diffusion facilitator family transporter
- antiporter
- protein homodimerization
- protein binding
- zinc ion transporter
- Cation efflux family
- metal ion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- acute myeloid leukemia
- insulin resistance
- metabolic syndrome X
- late-onset noninsulin-dependent diabetes mellitus
- gestational diabetes mellitus
- asthma
regulated by
- D-glucose
- cholesterol
- oxygen
- dioleoylphosphatidylglycerol
- lysophosphatidylcholine
- heavy metal
- YC-1
- phosphatidylinositol
- 1,2-dioleoylphosphatidylserine
- beta islet cells
regulates
- heavy metal
- insulin
- D-glucose
- Ins1
- Zn2+
- AMYLOID
- INS
role in cell
- number
- function
- diameter
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- secretory granule membrane
- Golgi membrane
- cytoplasmic vesicles
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc30a8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to zinc ion
- insulin processing
- insulin secretion
- response to interferon-gamma
- cellular zinc ion homeostasis
- regulation of vesicle-mediated transport
- response to glucose stimulus
- zinc ion transport
- glucose homeostasis
- zinc ion import
- response to interleukin-1
- zinc ion transmembrane transport
- positive regulation of insulin secretion
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- transport vesicle membrane
- intracellular membrane-bounded organelle
- secretory granule
- cytoplasmic vesicle
- Golgi membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- protein homodimerization activity
- zinc ion transmembrane transporter activity