Slc39a2 Gene Summary [Rat]

Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in cadmium ion transmembrane transport; keratinocyte differentiation; and zinc ion transmembrane transport. Predicted to act upstream of or within zinc ion transport. Predicted to be located in cytoplasmic ribonucleoprotein granule and cytoplasmic vesicle. Predicted to be active in plasma membrane. Orthologous to human SLC39A2 (solute carrier family 39 member 2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Slc39a2
Official Name
solute carrier family 39 member 2 [Source:RGD Symbol;Acc:1306291]
Ensembl ID
ENSRNOG00000010375
Bio databases IDs NCBI: 305846 Ensembl: ENSRNOG00000010375
Aliases solute carrier family 39 member 2
Synonyms 6A1, Eti-1, F730005G13, F730005G13Rik, Gm1789, Gm289, hZIP2, solute carrier family 39 member 2, solute carrier family 39 (zinc transporter), member 2, ZIP-2
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc39a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ZIP Zinc transporter
  • protein binding
  • zinc finger domain
  • zinc ion transporter
  • metal ion transporter
  • acidic domain
  • transporter

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • heavy metal
  • SB203580
  • 6-formylindolo[3,2-b]carbazole
  • FUS
  • N,N,N',N'-tetrakis(2-pyridyl-methyl)ethylenediamine
  • Langerhans cells
  • EOMES
regulates
  • Zn2+
  • heavy metal
role in cell
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cytoplasmic ribonucleoprotein granule
  • Nucleus
  • cytoplasmic vesicles

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Slc39a2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • keratinocyte differentiation
  • zinc ion transport
  • cadmium ion transmembrane transport
  • zinc ion transmembrane transport

Cellular Component

Where in the cell the gene product is active
  • cytoplasmic vesicle
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • zinc ion transmembrane transporter activity
  • metal ion transmembrane transporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.