Rtcb Gene Summary [Rat]
Predicted to enable RNA ligase (GTP) activity and vinculin binding activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to act upstream of or within in utero embryonic development and placenta development. Predicted to be located in cytosol; endoplasmic reticulum membrane; and nucleus. Predicted to be part of tRNA-splicing ligase complex. Predicted to be active in nucleus. Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rtcb |
| Official Name | RNA 2',3'-cyclic phosphate and 5'-OH ligase [Source:RGD Symbol;Acc:1303261] |
| Ensembl ID | ENSRNOG00000004813 |
| Bio databases IDs | |
| Aliases | RNA 2',3'-cyclic phosphate and 5'-OH ligase |
| Synonyms | C22orf28, D10Wsu52e, DJ149A16.6, FAAP, HSPC117, LOC362855, RNA 2',3'-cyclic phosphate and 5'-OH ligase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rtcb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA ligase
- tRNA-splicing ligase RtcB
- RNA ligase (ATP)
- PRK09588
- enzyme
- vinculin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
regulated by
- tamoxifen
- RAF1
- PD98059
- A549 cells
- AT2 cells
- MEL S3
- IND S7
role in cell
- expression in
- apoptosis
- binding in
- formation in
- formation
- replication in
- processing in
- tamoxifen sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rtcb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- tRNA splicing, via endonucleolytic cleavage and ligation
- placenta development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- tRNA-splicing ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- RNA binding
- protein binding
- metal ion binding
- vinculin binding
- RNA ligase (ATP) activity