Fshb Gene Summary [Rat]
Predicted to enable follicle-stimulating hormone activity. Predicted to be involved in several processes, including follicle-stimulating hormone signaling pathway; positive regulation of steroid biosynthetic process; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including gonad development; positive regulation of bone resorption; and regulation of osteoclast differentiation. Predicted to be part of follicle-stimulating hormone complex. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in amenorrhea and hypogonadotropic hypogonadism 24 without anosmia. Orthologous to human FSHB (follicle stimulating hormone subunit beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fshb |
| Official Name | follicle stimulating hormone subunit beta [Source:RGD Symbol;Acc:2630] |
| Ensembl ID | ENSRNOG00000004898 |
| Bio databases IDs | |
| Aliases | follicle stimulating hormone subunit beta |
| Synonyms | follicle stimulating hormone beta, follicle stimulating hormone subunit beta, follicle stimulating hormone subunit β, follicle stimulating hormone β, FSH, FSH-beta, FSH-β, HH24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fshb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- follicle-stimulating hormone
- protein binding
- glycosylation site
Pathways
Biological processes and signaling networks where the Fshb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- adenoma formation
- epithelial neoplasia
- epithelial cancer
- hypoplasia
- oligozoospermia
- isolated follicle-stimulating hormone deficiency
- epithelial ovarian cancer
- ovarian cancer
- epithelial ovarian or fallopian tube or primary peritoneal cancer
role in cell
- expression in
- proliferation
- binding in
- differentiation
- signaling in
- quantity
- mobility
- number
- generation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cytoplasmic vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fshb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Sertoli cell proliferation
- female gamete generation
- G-protein coupled receptor signaling pathway
- spermatogenesis
- positive regulation of cell proliferation
- transforming growth factor beta receptor signaling pathway
- female pregnancy
- positive regulation of transcription from RNA polymerase II promoter
- follicle-stimulating hormone signaling pathway
- progesterone biosynthetic process
- regulation of osteoclast differentiation
- positive regulation of gene expression
- positive regulation of bone resorption
- regulation of receptor activity
- positive regulation of steroid biosynthetic process
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- follicle-stimulating hormone complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- follicle-stimulating hormone activity