Amh Gene Summary [Rat]
Enables transforming growth factor beta receptor binding activity. Involved in several processes, including negative regulation of ovarian follicle development; positive regulation of NF-kappaB transcription factor activity; and preantral ovarian follicle growth. Acts upstream of or within urogenital system development. Located in extracellular space. Human ortholog(s) of this gene implicated in disorder of sexual development; ovarian carcinoma; and persistent Mullerian duct syndrome. Orthologous to human AMH (anti-Mullerian hormone). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amh |
| Official Name | anti-Mullerian hormone [Source:RGD Symbol;Acc:2108] |
| Ensembl ID | ENSRNOG00000019377 |
| Bio databases IDs | |
| Aliases | anti-Mullerian hormone |
| Synonyms | anti-Mullerian hormone, MIF, MIS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Amh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- punt binding
- transforming growth factor-beta receptor binding
- Anti-Mullerian hormone, N terminal region
- TGF_beta_SF
- Transforming growth factor beta like domain
- hormone
- protein binding
- receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Amh gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- polycystic ovary syndrome
- neoplasia
- pseudohermaphroditism
- persistent Mullerian duct syndrome type I
- bleeding
- breast cancer
- persistent Müllerian duct syndrome
- secondary sex reversal
- familial premature ovarian failure
- hyperplasia
role in cell
- expression in
- cell viability
- inhibition
- apoptosis
- growth
- survival
- S phase
- phosphorylation in
- proliferation
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Amh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell signaling
- response to organic cyclic compound
- sex determination
- response to xenobiotic stimulus
- Mullerian duct regression
- ovarian follicle development
- gonadal mesoderm development
- sex differentiation
- urogenital system development
- preantral ovarian follicle growth
- positive regulation of gene expression
- negative regulation of ovarian follicle development
- positive regulation of SMAD protein import into nucleus
- Leydig cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- type II transforming growth factor beta receptor binding
- receptor binding
- hormone activity