Lpcat4 Gene Summary [Rat]
Predicted to enable O-acyltransferase activity and lysophosphatidic acid acyltransferase activity. Predicted to be involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Predicted to act upstream of or within phospholipid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human LPCAT4 (lysophosphatidylcholine acyltransferase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lpcat4 |
| Official Name | lysophosphatidylcholine acyltransferase 4 [Source:RGD Symbol;Acc:1311177] |
| Ensembl ID | ENSRNOG00000005058 |
| Bio databases IDs | |
| Aliases | lysophosphatidylcholine acyltransferase 4 |
| Synonyms | AGPAT7, AYTL3, LOC254531, LPAAT-eta, LPEAT2, LPLAT10, lysophosphatidylcholine acyltransferase 4, RGD1311177 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lpcat4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 1-alkenylglycerophosphoethanolamine O-acyltransferase
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- 1-acylglycerophosphocholine O-acyltransferase
- enzyme
- Acyltransferase
- 1-alkylglycerophosphocholine O-acetyltransferase
- O-acyltransferase
- Non-amino-acyl group acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- gastric epithelial cancer
- hereditary paraganglioma-pheochromocytoma syndrome
- postprandial hyperglycemia
- cholangiocarcinoma
- cholangiocarcinoma cancer
- ovarian serous cystadenocarcinoma
- serous ovarian cancer
- thyroid carcinoma
- epithelial thyroid cancer
regulated by
- PAGA
- CD3 (family)
- NANOG
regulates
- insulin
- ACSL3
- phospholipid
- lysophosphatidylcholine
- 40:7 phosphatidylcholine
- lysophosphatidylserine
- lysophosphatidylethanolamine
- 1-alkyl-2-lyso-sn-glycero-3-phosphocholine
- 2-22:6(4Z,7Z,10Z,13Z,16Z,19Z) lysophosphatidylcholine
- 18:1 lysophosphatidylethanolamine
role in cell
- expression in
- growth
- biosynthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lpcat4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylcholine acyl-chain remodeling
- phosphatidylethanolamine acyl-chain remodeling
- phosphatidylserine acyl-chain remodeling
- phosphatidylglycerol acyl-chain remodeling
- phospholipid metabolic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- lysophospholipid acyltransferase activity
- 1-acylglycerophosphocholine O-acyltransferase activity
- lysophosphatidic acid acyltransferase activity
- 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
- 2-acylglycerol-3-phosphate O-acyltransferase activity
- 1-alkylglycerophosphocholine O-acetyltransferase activity