LPCAT4 Gene Summary [Human]
Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
Details
| Type | Protein Coding |
| Official Symbol | LPCAT4 |
| Official Name | lysophosphatidylcholine acyltransferase 4 [Source:HGNC Symbol;Acc:HGNC:30059] |
| Ensembl ID | ENSG00000176454 |
| Bio databases IDs | |
| Aliases | lysophosphatidylcholine acyltransferase 4, lysophosphatidylethanolamine acyltransferase 2 |
| Synonyms | AGPAT7, AYTL3, LOC254531, LPAAT-eta, LPEAT2, LPLAT10, lysophosphatidylcholine acyltransferase 4, RGD1311177 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LPCAT4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 1-alkenylglycerophosphoethanolamine O-acyltransferase
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- 1-acylglycerophosphocholine O-acyltransferase
- enzyme
- Acyltransferase
- 1-alkylglycerophosphocholine O-acetyltransferase
- O-acyltransferase
- Non-amino-acyl group acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- gastric epithelial cancer
- hereditary paraganglioma-pheochromocytoma syndrome
- postprandial hyperglycemia
- cholangiocarcinoma
- cholangiocarcinoma cancer
- ovarian serous cystadenocarcinoma
- serous ovarian cancer
- thyroid carcinoma
- epithelial thyroid cancer
regulates
- insulin
- ACSL3
- phospholipid
- lysophosphatidylcholine
- 40:7 phosphatidylcholine
- lysophosphatidylserine
- lysophosphatidylethanolamine
- 1-alkyl-2-lyso-sn-glycero-3-phosphocholine
- 2-22:6(4Z,7Z,10Z,13Z,16Z,19Z) lysophosphatidylcholine
- 18:1 lysophosphatidylethanolamine
role in cell
- expression in
- growth
- biosynthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LPCAT4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylcholine acyl-chain remodeling
- phosphatidylethanolamine acyl-chain remodeling
- phosphatidylserine acyl-chain remodeling
- phosphatidylglycerol acyl-chain remodeling
- phospholipid metabolic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- lysophospholipid acyltransferase activity
- 1-acylglycerophosphocholine O-acyltransferase activity
- lysophosphatidic acid acyltransferase activity
- 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
- 2-acylglycerol-3-phosphate O-acyltransferase activity
- 1-alkylglycerophosphocholine O-acetyltransferase activity