Acsl3 Gene Summary [Rat]
Enables arachidonate-CoA ligase activity. Involved in fatty acid biosynthetic process; long-chain fatty acid metabolic process; and response to nutrient. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Human ortholog(s) of this gene implicated in asthma; breast cancer; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acsl3 |
| Official Name | acyl-CoA synthetase long-chain family member 3 [Source:RGD Symbol;Acc:70552] |
| Ensembl ID | ENSRNOG00000014718 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase long-chain family member 3 |
| Synonyms | 2610510B12Rik, ACS3, ACYL-COA SYNTHETASE 3, acyl-CoA synthetase long-chain family member 3, FACL3, LACS 3, PRO2194 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acsl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain-fatty-acid-CoA ligase
- arachidonate-CoA ligase
- protein kinase binding
- benzoate-CoA ligase family
- AMP-binding enzyme
- Adenylate forming domain, Class I superfamily
- acyl-CoA ligase (AMP-forming), exosortase A-associated
- protein domain specific binding
- enzyme
- protein binding
- LR domain
- amino acid adenylation domain
Pathways
Biological processes and signaling networks where the Acsl3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoarthritis
- systemic lupus erythematosus
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- allergic rhinitis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- hepatitis B virus-related hepatocellular carcinoma
regulates
- prostaglandin E2
- 18:0/20:4 phosphatidylinositol
- long chain fatty acid
- ACSL
- phosphatidylcholine
- PKLR
- ceramide
- fatty acid
- oleic acid
- pentadecanoic acid
role in cell
- cell viability
- expression in
- production in
- formation
- invasion by
- ferroptosis
- formation in
- lipotoxicity in
- lipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- lipid droplets
- endoplasmic reticulum membrane
- microsome
- mitochondrial outer membrane
- synaptic vesicles
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acsl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid import
- positive regulation of Golgi to plasma membrane protein transport
- long-chain fatty acid metabolic process
- positive regulation of secretion
- neuron differentiation
- long-chain fatty-acyl-CoA biosynthetic process
- positive regulation of phosphatidylcholine biosynthetic process
- very-low-density lipoprotein particle assembly
- long-chain fatty-acyl-CoA metabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- peroxisomal membrane
- perinuclear region of cytoplasm
- membrane
- Golgi apparatus
- endoplasmic reticulum
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- medium-chain fatty acid-CoA ligase activity
- protein kinase binding
- ATP binding
- protein domain specific binding
- protein binding
- arachidonate-CoA ligase activity
- long-chain fatty acid-CoA ligase activity