Dlg5 Gene Summary [Rat]
Predicted to enable beta-catenin binding activity and cytoskeletal protein binding activity. Predicted to be involved in several processes, including positive regulation of dendritic spine development; positive regulation of smoothened signaling pathway; and regulation of hippo signaling. Predicted to act upstream of or within several processes, including apical protein localization; epithelial cell differentiation; and nervous system development. Predicted to be located in adherens junction and ciliary basal body. Predicted to be active in glutamatergic synapse and postsynaptic density. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlg5 |
| Official Name | discs large MAGUK scaffold protein 5 [Source:RGD Symbol;Acc:1308753] |
| Ensembl ID | ENSRNOG00000005783 |
| Bio databases IDs | |
| Aliases | discs large MAGUK scaffold protein 5 |
| Synonyms | 4933429D20Rik, discs large MAGUK scaffold protein 5, KIAA0583, LP-DLG, mKIAA0583, PDLG, P-DLG5, YUVOB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dlg5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Takusan
- Flagellar FliJ protein
- Ciliary protein causing Leber congenital amaurosis disease
- Bin/Amphiphysin/Rvs domain
- Laminin Domain I
- guanylate kinase
- cytoskeletal protein binding
- Unstructured region between two PDZ domains on Dlg5
- HOOK protein coiled-coil region
- Mitotic checkpoint protein
- Centrosome localization domain of PPC89
- Domain present in PSD-95, Dlg, and ZO-1/2
- Ezrin/radixin/moesin, alpha-helical domain
- PspA/IM30 family
- beta-catenin binding
- canonical PDZ domain
- SWI5-dependent HO expression protein 3
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- PDZ domain
- Src Homology 3 domain superfamily
- NK
- Growth-arrest specific micro-tubule binding
- domain 2
- Intermediate filament protein
- PDZ binding motif
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Dlg5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Yuksel-Vogel-Bauer syndrome
- alcoholic liver disease
- retinal detachment
role in cell
- formation
- growth
- differentiation
- proliferation
- formation in
- migration
- clustering in
- development
- assembly
- synaptogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell junction
- Cytoplasm
- cellular membrane
- basal bodies
- intercellular junctions
- cell-cell contacts
- postsynaptic density
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dlg5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
- epithelial tube branching involved in lung morphogenesis
- neuroepithelial cell differentiation
- positive regulation of hippo signaling cascade
- macromolecular complex assembly
- signal transduction
- negative regulation of cell proliferation
- positive regulation of dendritic spine development
- regulation of apoptotic process
- midbrain development
- polarized epithelial cell differentiation
- zonula adherens assembly
- establishment or maintenance of epithelial cell apical/basal polarity
- negative regulation of T cell proliferation
- positive regulation of smoothened signaling pathway
- apical protein localization
- maintenance of cell polarity
- metanephric collecting duct development
- epithelial to mesenchymal transition
- protein localization to adherens junction
- positive regulation of synapse assembly
- intracellular signal transduction
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- adherens junction
- cilium basal body
- cytoplasm
- cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-catenin binding
- cytoskeletal protein binding
- receptor signaling complex scaffold activity