Bzw2 Gene Summary [Rat]
Predicted to be involved in regulation of translational initiation. Predicted to be active in cytoplasm. Orthologous to human BZW2 (basic leucine zipper and W2 domains 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bzw2 |
| Official Name | basic leucine zipper and W2 domains 2 [Source:RGD Symbol;Acc:621507] |
| Ensembl ID | ENSRNOG00000005096 |
| Bio databases IDs | |
| Aliases | basic leucine zipper and W2 domains 2 |
| Synonyms | 1110001I24Rik, 5MP1, basic leucine zipper and W2 domains 2, Bdm2, HFB2, HSPC028, MST017, MSTP017 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bzw2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- eIF4-gamma/eIF5/eIF2-epsilon
- protein binding
- C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- inflammatory bowel disease
- organismal death
- dementia
- ulcerative colitis
- colorectal cancer
- Alzheimer disease
role in cell
- proliferation
- expression in
- invasion by
- sphere formation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bzw2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding