Bzw2 Gene Summary [Mouse]
Predicted to be involved in regulation of translational initiation. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; cardiovascular system; and genitourinary system. Orthologous to human BZW2 (basic leucine zipper and W2 domains 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bzw2 |
| Official Name | basic leucine zipper and W2 domains 2 [Source:MGI Symbol;Acc:MGI:1914162] |
| Ensembl ID | ENSMUSG00000020547 |
| Bio databases IDs | |
| Aliases | basic leucine zipper and W2 domains 2 |
| Synonyms | 1110001I24Rik, 5MP1, basic leucine zipper and W2 domains 2, Bdm2, HFB2, HSPC028, MST017, MSTP017 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bzw2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- eIF4-gamma/eIF5/eIF2-epsilon
- protein binding
- C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- inflammatory bowel disease
- organismal death
- dementia
- ulcerative colitis
- colorectal cancer
- Alzheimer disease
phenotypes
- abnormal sinus arrhythmia
- abnormal sleep behavior
- decreased circulating cholesterol level
- decreased circulating glucose level
- decreased circulating iron level
- decreased exploration in new environment
- decreased total body fat amount
- increased bone mineral content
- increased bone mineral density
- increased circulating alkaline phosphatase level
- increased coping response
- increased heart rate
- increased lean body mass
- shortened RR interval
- abnormal adipose tissue amount
- abnormal coping response
- abnormal lean body mass
- abnormal response to new environment
- cardiovascular system phenotype
- decreased circulating HDL cholesterol level
role in cell
- proliferation
- expression in
- invasion by
- sphere formation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bzw2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding