Sec23a Gene Summary [Rat]
Predicted to enable GTPase activator activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading and protein localization to plasma membrane. Predicted to be located in several cellular components, including bounding membrane of organelle; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in craniolenticulosutural dysplasia. Orthologous to human SEC23A (SEC23 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec23a |
| Official Name | Sec23 homolog A, coat complex II component [Source:RGD Symbol;Acc:1309103] |
| Ensembl ID | ENSRNOG00000004657 |
| Bio databases IDs | |
| Aliases | Sec23 homolog A, coat complex II component |
| Synonyms | CLSD, hSec23A, Msec23, Sec23, SEC23 homolog A, COPII coat complex component, Sec23r |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sec23a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec23/Sec24 helical domain
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- Sec23/Sec24 trunk domain
- zinc ion binding
- Gelsolin repeat
- vWFA
- Sec23/Sec24 beta-sandwich domain
- protein binding
- Sec23/Sec24 zinc finger
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- gastric epithelial cancer
- craniolenticulosutural dysplasia
- insomnia
- organismal death
- neonatal late-onset sepsis
role in cell
- proliferation
- expression in
- migration
- accumulation in
- colony formation
- morphology
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- juxtanuclear Golgi region
- endoplasmic reticulum mitochondria contact site
- perinuclear region
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum exit sites
- Golgi membrane
- transport vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sec23a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cargo loading into COPII-coated vesicle
- intracellular protein transport
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- ER to Golgi transport vesicle membrane
- cytosol
- endoplasmic reticulum exit site
- Golgi membrane
- COPII vesicle coat
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- GTPase activator activity