Desi1 Gene Summary [Rat]
Predicted to enable several functions, including deSUMOylase activity; importin-alpha family protein binding activity; and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in protein desumoylation; protein export from nucleus; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Orthologous to human DESI1 (desumoylating isopeptidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Desi1 |
| Official Name | desumoylating isopeptidase 1 [Source:RGD Symbol;Acc:1305776] |
| Ensembl ID | ENSRNOG00000005577 |
| Bio databases IDs | |
| Aliases | desumoylating isopeptidase 1 |
| Synonyms | CLONE RP3-347H13, D15Wsu75e, DESI2, desumoylating isopeptidase 1, DJ347H13.4, FAM152B, POST, PPPDE2, RGD1305776 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Desi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO-specific protease
- peptidase
- PPPDE putative peptidase domain
- protein binding
- identical protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Desi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein desumoylation
- proteolysis
- protein export from nucleus
- regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein modification by small protein removal
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- palmitoyl-(protein) hydrolase activity
- long-chain acyl-CoA hydrolase activity
- SUMO-specific protease activity