Ca8 Gene Summary [Rat]
Predicted to enable carbonate dehydratase activity and zinc ion binding activity. Predicted to act upstream of or within positive regulation of calcium-mediated signaling. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 34. Orthologous to human CA8 (carbonic anhydrase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ca8 |
| Official Name | carbonic anhydrase 8 [Source:RGD Symbol;Acc:1304709] |
| Ensembl ID | ENSRNOG00000005669 |
| Bio databases IDs | |
| Aliases | carbonic anhydrase 8 |
| Synonyms | CALS, Cals1, CAMRQ3, Car8, carbonic anhydrase 8, CA-RP, CA-VIII, SCAR34, wdl |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ca8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carbonate dehydratase
- Eukaryotic-type carbonic anhydrase
- alpha_CA
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cerebellar ataxia, mental retardation, and dysequilibrium syndrome type 3
- Parkinson disease
- appendicular dystonia
- mild mental retardation
- ataxia
- cerebellar ataxia
- autosomal recessive nonsyndromic mental retardation
- quadrupedal gait
- ataxia-telangiectasia
regulates
- ITPR1
- 1,4,5-IP3
- ITPR
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ca8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of calcium-mediated signaling
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- hydro-lyase activity
- carbonate dehydratase activity