Klk7 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in positive regulation of antibacterial peptide production; regulation of systemic arterial blood pressure; and zymogen activation. Predicted to be located in epidermal lamellar body. Predicted to be active in cornified envelope; extracellular space; and secretory granule. Orthologous to human KLK7 (kallikrein related peptidase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klk7 |
| Official Name | kallikrein-related peptidase 7 [Source:RGD Symbol;Acc:1306420] |
| Ensembl ID | ENSRNOG00000018664 |
| Bio databases IDs | |
| Aliases | kallikrein-related peptidase 7 |
| Synonyms | hK7, kallikrein-related peptidase 7, kallikrein related-peptidase 7 (chymotryptic, stratum corneum), PRSS6, SCCE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klk7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- tissue kallikrein
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Klk7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- atopic dermatitis
- ovarian cancer
- psoriasis
- serous ovarian cancer
- organismal death
- delayed hypersensitive reaction
- pruritus
- hyperkeratosis
role in cell
- migration
- proliferation
- survival
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cornified envelope
- alveolar epithelial lamellar bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klk7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix disassembly
- proteolysis
- positive regulation of antibacterial peptide production
- epidermis development
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- extracellular space
- secretory granule
- epidermal lamellar body
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type peptidase activity
- serine-type endopeptidase activity
- peptidase activity
- metalloendopeptidase activity