Cpne3 Gene Summary [Rat]
Predicted to enable several functions, including calcium-dependent phospholipid binding activity; calcium-dependent protein binding activity; and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including ERBB2 signaling pathway; cellular response to calcium ion; and positive regulation of cell migration. Predicted to be located in several cellular components, including focal adhesion; mitochondrion; and nuclear lumen. Predicted to be active in plasma membrane. Orthologous to human CPNE3 (copine 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpne3 |
| Official Name | copine 3 [Source:RGD Symbol;Acc:1310178] |
| Ensembl ID | ENSRNOG00000006298 |
| Bio databases IDs | |
| Aliases | copine 3 |
| Synonyms | 5430428M23Rik, 5730450C07Rik, C85108, copine 3, copine III, CPN3, PRO1071 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpne3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Copine
- calcium-dependent protein binding
- protein serine/threonine kinase
- receptor tyrosine kinase binding
- von Willebrand factor (vWF) type A domain
- vWFA
- calcium-dependent phospholipid binding
- protein binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- mammary neoplasm
- adult T-cell leukemia/lymphoma
- prostatic neoplasm
- prostatic neoplasia
- ovarian neoplasm
- ovarian neoplasia
- hyperglycemia
role in cell
- expression in
- activation in
- migration
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- focal adhesions
- Nucleus
- Plasma Membrane
- Mitochondria
- secretory granule membrane
- cytosol
- lysosome membrane
- nucleoplasm
- nucleoli
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpne3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to calcium ion
- cellular response to growth factor stimulus
- ERBB2 signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- mitochondrion
- cell junction
- cytosol
- nucleolus
- azurophil granule membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- calcium-dependent protein binding
- protein serine/threonine kinase activity
- receptor tyrosine kinase binding
- calcium-dependent phospholipid binding