Mmp19 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Involved in female gonad development; response to cAMP; and response to hormone. Predicted to be located in extracellular matrix. Orthologous to human MMP19 (matrix metallopeptidase 19). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp19 |
| Official Name | matrix metallopeptidase 19 [Source:RGD Symbol;Acc:1311376] |
| Ensembl ID | ENSRNOG00000006778 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 19 |
| Synonyms | CODA, matrix metallopeptidase 19, MMP18, RASI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmp19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative peptidoglycan binding domain
- Matrixin
- Hemopexin-like repeats
- ZnMc
- serine endopeptidase
- catalytic domain
- peptidase
- HX
- Zinc-dependent metalloprotease
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp19 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung cancer
- organismal death
- breast cancer
- osteoarthritis
- cavitary optic disc anomalies
- obesity
- eczema
- delayed hypersensitive reaction
- androgenic alopecia
role in cell
- proliferation
- activation
- number
- migration
- cellular infiltration by
- quantity
- differentiation
- maturation
- hypertrophy
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mmp19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- extracellular matrix disassembly
- proteolysis
- cell differentiation
- extracellular matrix organization
- collagen catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- serine-type endopeptidase activity
- metalloendopeptidase activity