Coch Gene Summary [Rat]
Predicted to enable collagen binding activity. Predicted to be involved in regulation of cell shape. Predicted to act upstream of or within sensory perception of sound. Predicted to be located in extracellular matrix. Predicted to be active in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 9 and autosomal recessive nonsyndromic deafness 110. Orthologous to human COCH (cochlin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coch |
| Official Name | cochlin [Source:RGD Symbol;Acc:1308536] |
| Ensembl ID | ENSRNOG00000005286 |
| Bio databases IDs | |
| Aliases | cochlin |
| Synonyms | COCH-5B2, COCHLIN, D12H14S564E, DFNA9, DFNB110, Lulu |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Coch often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor (vWF) type A domain
- vWFA
- collagen binding
- LCCL domain
- protein binding
- von Willebrand factor type A domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Alzheimer disease
- hepatocellular carcinoma
- Huntington disease
- breast cancer
- small cell lung cancer
- plasma cell myeloma
- familial nonsyndromic hearing impairment
- glaucoma
- lung squamous cell carcinoma
role in cell
- recruitment
- expression in
- differentiation
- cytotoxic reaction
- clearance
- colonization by
- cell survival
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum/Golgi apparatus fractions
- Cytoplasm
- cellular membrane
- Nucleus
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Coch gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- sensory perception of sound
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- collagen binding