Ppm1k Gene Summary [Rat]
Predicted to enable manganese ion binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in branched-chain amino acid catabolic process and regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppm1k |
| Official Name | protein phosphatase, Mg2+/Mn2+ dependent, 1K [Source:RGD Symbol;Acc:1308501] |
| Ensembl ID | ENSRNOG00000006893 |
| Bio databases IDs | |
| Aliases | protein phosphatase, Mg2+/Mn2+ dependent, 1K |
| Synonyms | 2900063A19Rik, A930026L03Rik, BCKDH, BDP, MSUDMV, PP2C-kappa, PP2Cm, PP2C-κ, protein phosphatase 1K (PP2C domain containing), protein phosphatase, Mg2+/Mn2+ dependent 1K, protein phosphatase, Mg2+/Mn2+ dependent, 1K, PTMP, RGD1308501, UG0882E07 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppm1k often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sigma factor PP2C-like phosphatases
- Protein phosphatase 2C
- protein serine/threonine phosphatase
- phosphatase
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- manganese ion binding
- PP2Cc
Pathways
Biological processes and signaling networks where the Ppm1k gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mild variant maple syrup urine disease
- systemic lupus erythematosus
- metabolic syndrome X
- gestational diabetes mellitus
- conduct disorder
- infection by HIV-1
regulates
- branched chain amino acids
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppm1k gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-threonine dephosphorylation
- branched chain family amino acid catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity
- protein serine/threonine phosphatase activity
- protein binding
- manganese ion binding
- myosin phosphatase activity