Fgb Gene Summary [Rat]
Predicted to enable protein-folding chaperone binding activity and structural molecule activity. Predicted to contribute to cell adhesion molecule binding activity and signaling receptor binding activity. Involved in cellular response to interleukin-1 and cellular response to leptin stimulus. Located in blood microparticle. Biomarker of pancreatitis and pulmonary embolism. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgb |
| Official Name | fibrinogen beta chain [Source:RGD Symbol;Acc:2604] |
| Ensembl ID | ENSRNOG00000007092 |
| Bio databases IDs | |
| Aliases | fibrinogen beta chain |
| Synonyms | 2510049G14Rik, Ab1-181, Ab1-216, Ac1-581, Beta fibrinogen, FBC, Fg beta chain, Fg β chain, FIBRINOGEN beta CHAIN, Fibrinogen b β, FIBRINOGEN β CHAIN, Fibronogen B β, HEL-S-78p, β-fibrinogen |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fibrinogen alpha/beta chain family
- cell adhesion molecule binding
- heparin binding domain
- protein binding
- receptor binding
- chaperone binding
- structural molecule
- FReD
Pathways
Biological processes and signaling networks where the Fgb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- colorectal neoplasm
- epithelial cancer
- congenital afibrinogenemia
- Alzheimer disease
- moderately severe hemophilia A
- proliferative diabetic retinopathy
- vascular leak syndrome
- venous thromboembolism
- ischemic stroke
role in cell
- formation in
- formation
- phosphorylation in
- activation in
- binding in
- assembly
- cellular infiltration by
- exocytosis by
- adhesion
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- blood microparticle
- cell surface
- cell cortex
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- plasma membrane extracellular face
- alpha granules
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- macromolecular complex assembly
- positive regulation of vasoconstriction
- positive regulation of peptide hormone secretion
- adaptive immune response
- positive regulation of substrate adhesion-dependent cell spreading
- fibrinolysis
- positive regulation of exocytosis
- protein polymerization
- blood coagulation, fibrin clot formation
- induction of bacterial agglutination
- plasminogen activation
- response to calcium ion
- cellular response to leptin stimulus
- innate immune response
- positive regulation of ERK1 and ERK2 cascade
- cellular response to interleukin-1
- positive regulation of heterotypic cell-cell adhesion
- positive regulation of protein secretion
- negative regulation of endothelial cell apoptotic process
- platelet aggregation
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- platelet alpha granule
- external side of plasma membrane
- endoplasmic reticulum
- synapse
- extracellular region
- plasma membrane
- cell surface
- fibrinogen complex
- extracellular space
- extracellular vesicular exosome
- cell cortex
- blood microparticle
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding
- cell adhesion molecule binding
- structural molecule activity
- extracellular matrix structural constituent
- receptor binding