Cp Gene Summary [Rat]
Enables copper ion binding activity. Involved in several processes, including female pregnancy; mammary gland development; and response to copper ion. Located in cell surface and extracellular space. Used to study brain edema. Biomarker of Wilson disease; brain ischemia; heart disease; and hyperthyroidism. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cp |
| Official Name | ceruloplasmin [Source:RGD Symbol;Acc:2387] |
| Ensembl ID | ENSRNOG00000011913 |
| Bio databases IDs | |
| Aliases | ceruloplasmin |
| Synonyms | AB073614, CERP, ceruloplasmin, CP-2, D3Ertd555e, Ferroxidase, FOX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid-hydroperoxide glutathione peroxidase
- copper ion binding
- Multicopper oxidase
- Cupredoxin superfamily
- metal ion oxidising:oxygen oxidoreductase
- enzyme
- chaperone binding
- glutathione peroxidase
- ferroxidase
Pathways
Biological processes and signaling networks where the Cp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- acute myeloid leukemia
- COVID-19
- chronic sinusitis
- renal clear cell adenocarcinoma
- deficiency of ferroxidase
- epithelial cancer
- rheumatoid arthritis
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- transport in
- number
- aggregation
- degeneration
- organization
- abnormal morphology
- accumulation in
- function
- inflammatory response
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- intracellular compartment
- cell surface
- intracellular space
- Nucleus
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- copper ion transport
- cellular copper ion homeostasis
- iron ion transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- extracellular region
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phospholipid-hydroperoxide glutathione peroxidase activity
- oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
- glutathione peroxidase activity
- copper ion binding
- oxidoreductase activity
- chaperone binding
- ferroxidase activity