Tfpi2 Gene Summary [Rat]
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | Tfpi2 |
| Official Name | tissue factor pathway inhibitor 2 [Source:RGD Symbol;Acc:628629] |
| Ensembl ID | ENSRNOG00000010513 |
| Bio databases IDs | |
| Aliases | tissue factor pathway inhibitor 2 |
| Synonyms | PP5, PP5/TFPI-2, REF1, tissue factor pathway inhibitor 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tfpi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- extracellular matrix structural constituent
- Kunitz protease inhibitor domain
Pathways
Biological processes and signaling networks where the Tfpi2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- renal fibrosis
- serous ovarian adenocarcinoma
- serous ovarian cancer
- lung cancer
- osteoarthritis
- prostatic carcinoma
- colon cancer
- liver cancer
role in cell
- proliferation
- migration
- growth
- expression in
- phosphorylation in
- apoptosis
- survival
- quantity
- invasion
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent-insoluble fractions
- extracellular matrix
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tfpi2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to fluid shear stress
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- extracellular matrix structural constituent