Dut Gene Summary [Rat]
Enables several functions, including dUTP diphosphatase activity; peroxisome proliferator activated receptor binding activity; and pyrimidine deoxyribonucleotide binding activity. Involved in liver development; pyrimidine deoxyribonucleotide metabolic process; and regulation of protein-containing complex assembly. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dut |
| Official Name | deoxyuridine triphosphatase [Source:RGD Symbol;Acc:620849] |
| Ensembl ID | ENSRNOG00000007221 |
| Bio databases IDs | |
| Aliases | deoxyuridine triphosphatase |
| Synonyms | 5031412I06Rik, 5133400F09Rik, BMFDMS, D2Bwg0749e, DEOXYURIDINE NUCLEOTIDOHYDROLASE, Deoxyuridine triphosphatase, DUTP, dUTPase, PIP4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dut often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- dUTP diphosphatase
- peroxisome proliferator activated receptor binding
- binding protein
- receptor inhibitor
- enzyme
- protein binding
- pyrimidine nucleotide binding
- Trimeric dUTP diphosphatases
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- plexiform neurofibroma
- adenoma formation
- bone marrow failure and diabetes mellitus syndrome
- cervical intraepithelial neoplasia
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
role in cell
- apoptosis
- survival
- tubulation
- fragmentation
- tubulation in
- fragmentation in
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dut gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- dTMP biosynthetic process
- dUMP biosynthetic process
- nucleobase-containing compound metabolic process
- dUTP catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein binding
- RNA binding
- dUTP diphosphatase activity