Il22 Gene Summary [Rat]
Predicted to enable cytokine activity. Involved in response to glucocorticoid. Located in extracellular space. Used to study asthma and myocarditis. Orthologous to human IL22 (interleukin 22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il22 |
| Official Name | interleukin 22 [Source:RGD Symbol;Acc:1561292] |
| Ensembl ID | ENSRNOG00000007365 |
| Bio databases IDs | |
| Aliases | interleukin 22 |
| Synonyms | If2b1, IL-D110, IL-TIF, interleukin 22, RGD1561292, TIFa, TIFIL-23, zcyto18 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- cytokine
- Interleukin 10
Pathways
Biological processes and signaling networks where the Il22 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kidney disease
- weight loss
- edema
- cancer
- hepatic steatosis
- neoplasia
- insulin-dependent diabetes mellitus
- epithelial neoplasia
- experimental autoimmune encephalomyelitis
- fibrosis
role in cell
- expression in
- migration
- differentiation
- apoptosis
- phosphorylation in
- proliferation
- production in
- chemotaxis
- activation in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- signal transduction
- negative regulation of inflammatory response
- response to glucocorticoid stimulus
- acute-phase response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interleukin-22 receptor binding
- protein binding
- cytokine activity