Plp1 Gene Summary [Rat]
A structural constituent of myelin sheath. Involved in several processes, including AMPA selective glutamate receptor signaling pathway; nervous system development; and positive regulation of calcium ion transmembrane transport. Located in myelin sheath. Part of integrin alphav-beta3 complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plp1 |
| Official Name | proteolipid protein 1 [Source:RGD Symbol;Acc:3354] |
| Ensembl ID | ENSRNOG00000002419 |
| Bio databases IDs | |
| Aliases | proteolipid protein 1 |
| Synonyms | GPM6C, HLD1, jimpy, jp, MMPL, msd, PLP, PLP/DM20, PMD, proteolipid protein 1, proteolipid protein (myelin) 1, rsh, SPG2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- structural constituent of myelin sheath
- protein binding
- structural molecule
- identical protein binding
- antigenic epitope
- Myelin proteolipid protein (PLP or lipophilin)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Pelizaeus-Merzbacher disease
- hereditary spastic paraplegia X-linked
- experimental autoimmune encephalomyelitis
- colorectal cancer
- demyelination
- gliosis
- neurodegeneration
- Huntington disease
- uterine leiomyoma
- leiomyomatosis
role in cell
- formation
- expression in
- fragmentation
- fragmentation in
- proliferation
- migration
- survival
- morphology
- activation
- cellular infiltration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- myelin enriched fraction
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- synaptic vesicles
- myelin sheath
- internodes
- matrix vesicles
- late endosomes
- membrane processes
- perikaryon
- axons
- axon branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system myelination
- astrocyte development
- inflammatory response
- long-chain fatty acid biosynthetic process
- positive regulation of gene expression
- synaptic transmission
- axon ensheathment
- substantia nigra development
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- myelin sheath
- alphav-beta3 integrin complex
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity
- structural constituent of myelin sheath