Patj Gene Summary [Rat]
Predicted to be involved in several processes, including establishment of apical/basal cell polarity; positive regulation of epithelial cell migration; and tight junction assembly. Part of protein-containing complex. Orthologous to human PATJ (PATJ crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Patj |
| Official Name | PATJ, crumbs cell polarity complex component [Source:RGD Symbol;Acc:1565362] |
| Ensembl ID | ENSRNOG00000007551 |
| Bio databases IDs | |
| Aliases | PATJ, crumbs cell polarity complex component |
| Synonyms | CIPP, hINADL, INADL, Inadl2, InaD-like, PATJ crumbs cell polarity complex component, PATJ, crumbs cell polarity complex component, RGD1564282, RGD1565362 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Patj often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- MAGUK recruitment domain
- Unstructured region 10 on multiple PDZ protein
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- L27_2
- cpPDZ_RseP_YlbL-like
- L27 domain
Pathways
Biological processes and signaling networks where the Patj gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- biliary atresia
- aphasia
- early missed abortion
- idiopathic scoliosis
- daytime sleepiness
- COVID-19
- metabolic syndrome X
- Bell palsy
- irritable bowel syndrome characterized by constipation
role in cell
- activation in
- migration
- formation in
- formation
- tubulation
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- perinuclear membrane
- apical compartment
- perinuclear region
- cellular membrane
- centrosome
- intercellular junctions
- cytosol
- apical membrane
- paranodal loops
- paranodes
- Schmidt-Lanterman incisures
- tight junctions
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Patj gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of apical/basal cell polarity
- establishment or maintenance of epithelial cell apical/basal polarity
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- tight junction
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- apical part of cell
- cytoplasm
- centriolar satellite
- apical junction complex
- cytosol
- cell junction
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding