Col4a3 Gene Summary [Rat]
Predicted to enable integrin binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in response to glucose. Predicted to be located in basement membrane and endoplasmic reticulum. Predicted to be part of collagen type IV trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Used to study glomerulonephritis. Human ortholog(s) of this gene implicated in Alport syndrome; autosomal dominant Alport syndrome; autosomal recessive Alport syndrome; benign familial hematuria; and end stage renal disease. Orthologous to human COL4A3 (collagen type IV alpha 3 chain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Col4a3 |
| Official Name | collagen type IV alpha 3 chain [Source:RGD Symbol;Acc:71085] |
| Ensembl ID | ENSRNOG00000015365 |
| Bio databases IDs | |
| Aliases | collagen type IV alpha 3 chain |
| Synonyms | [a]3(IV), alpha3(IV), ATS2, ATS3, ATS3A, ATS3B, BFH2, Col IValpha3, Collagen Type IV alpha3, collagen, type IV, alpha 3, collagen type IV alpha 3 chain, COLLAGEN type IV, ISOTYPE 3, Collagen type iv α 3, collagen, type IV, α 3, collagen type IV α 3 chain, Goodpasture antigen, LOC100911572 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Col4a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- n-terminal subdomain
- NC1 domain
- goodpasture epitope
- noncollagenous domain
- integrin binding
- RGD motif
- Collagen triple helix repeat (20 copies)
- C-terminal tandem repeated domain in type 4 procollagen
- protein binding
Pathways
Biological processes and signaling networks where the Col4a3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- dementia
- neoplasia
- autosomal recessive Alport syndrome
- hereditary disorder
- autosomal recessive Alport syndrome type 3B
- autosomal dominant Alport syndrome
- COL4A3-related disorder
- Peyronie disease
- Dupuytren contracture
role in cell
- proliferation
- apoptosis
- quantity
- migration
- survival
- morphology
- expression in
- phosphorylation in
- chemotaxis
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- cell surface
- cell cortex
- Endoplasmic Reticulum
- lipid droplets
- granules
- endoplasmic reticulum lumen
- basement membrane
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Col4a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of cell proliferation
- blood circulation
- cell surface receptor signaling pathway
- cell adhesion
- collagen-activated tyrosine kinase receptor signaling pathway
- glomerular basement membrane development
- sensory perception of sound
- response to glucose stimulus
- extracellular matrix organization
- endothelial cell apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- basement membrane
- extracellular space
- intracellular membrane-bounded organelle
- endoplasmic reticulum
- extracellular region
- collagen type IV
Molecular Function
What the gene product does at the molecular level
- protein binding
- extracellular matrix structural constituent conferring tensile strength
- structural molecule activity
- integrin binding
- metalloendopeptidase inhibitor activity