Stx8 Gene Summary [Rat]
Predicted to enable several functions, including SNAP receptor activity; chloride channel inhibitor activity; and ubiquitin protein ligase binding activity. Involved in endosome to lysosome transport and vesicle fusion. Located in late endosome membrane and lysosomal membrane. Part of SNARE complex. Orthologous to human STX8 (syntaxin 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx8 |
| Official Name | syntaxin 8 [Source:RGD Symbol;Acc:61917] |
| Ensembl ID | ENSRNOG00000003849 |
| Bio databases IDs | |
| Aliases | syntaxin 8 |
| Synonyms | 0610007H08Rik, 1110002H11Rik, 4930571E13Rik, CARB, syntaxin 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stx8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- ubiquitin protein ligase binding
- cytoplasmic domain
- Helical region found in SNAREs
- protein binding
- cytosolic tail domain
- SNARE motif
- chloride channel inhibitor activity
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- chronic pain
- inflammatory pain
- borderline personality disorder
- hyperopia
role in cell
- activation in
- apoptosis
- cell viability
- fusion
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- golgi/trans-golgi network-rich vesicle fraction
- membrane fraction
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- centrosome
- Endoplasmic Reticulum
- trans Golgi network
- lysosome membrane
- endosomal membrane
- perinuclear space
- spindle pole
- growth cone
- recycling endosomes
- early endosomes
- late endosomes
- clathrin-coated vesicles
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stx8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle fusion
- vesicle docking
- early endosome to late endosome transport
- cellular response to interferon-gamma
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- phagocytic vesicle
- late endosome
- endoplasmic reticulum
- plasma membrane
- trans-Golgi network
- early endosome
- perinuclear region of cytoplasm
- endosome
- endomembrane system
- SNARE complex
- vesicle
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- chloride channel inhibitor activity
- protein binding
- ubiquitin protein ligase binding
- syntaxin binding
- SNAP receptor activity
- SNARE binding