Rab11b Gene Summary [Rat]
Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in constitutive secretory pathway; regulated exocytosis; and regulation of presynaptic dense core granule exocytosis. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Orthologous to human RAB11B (RAB11B, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab11b |
| Official Name | RAB11B, member RAS oncogene family [Source:RGD Symbol;Acc:68369] |
| Ensembl ID | ENSRNOG00000007648 |
| Bio databases IDs | |
| Aliases | RAB11B, member RAS oncogene family |
| Synonyms | A730055L17RIK, H-YPT3, NDAGSCW, RAB11B, member RAS oncogene family, YPT3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab11b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- AAA domain
- GTP binding
- myosin binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab11b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- neurodevelopmental disorder with ataxic gait, absent speech and decreased cortical white matter
- metabolic syndrome X
- infection by Dengue virus 2
role in cell
- cell death
- apoptosis
- cell cycle progression
- formation
- replication in
- processing in
- entrance
- sialylation in
- alpha 2,3 sialylation in
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomal fractions
- synaptic vesicle membrane
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- granules
- cytosol
- endosomal membrane
- synaptic vesicles
- recycling endosomes
- cytoplasmic vesicles
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- microsomal membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab11b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin secretion involved in cellular response to glucose stimulus
- transferrin transport
- establishment of protein localization in membrane
- receptor recycling
- regulation of protein localization at cell surface
- constitutive secretory pathway
- regulated secretory pathway
- cellular response to acidity
- endocytic recycling
- regulation of anion transport
- regulation of endocytic recycling
- melanosome transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- synaptic vesicle
- phagocytic vesicle
- cytosol
- phagocytic vesicle membrane
- Golgi apparatus
- recycling endosome
- synaptic vesicle membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- cadherin binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding
- myosin V binding