St3gal4 Gene Summary [Rat]
Enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase. Predicted to be involved in several processes, including lipid biosynthetic process; positive regulation of leukocyte tethering or rolling; and protein modification process. Predicted to be located in Golgi cisterna membrane; Golgi membrane; and nucleus. Orthologous to human ST3GAL4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | St3gal4 |
| Official Name | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [Source:RGD Symbol;Acc:1303068] |
| Ensembl ID | ENSRNOG00000009850 |
| Bio databases IDs | |
| Aliases | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
| Synonyms | 2,3-Alpha Sialyltransferase, 2,3-α Sialyltransferase, Alpha-2,3-sialyltransferase, Beta-galactosidase alpha-2,3-sialytransferase, CGS23, gal-NAc6S, LOC100129068, NANTA3, SAT3, SIAT4, SIAT4-C, ST3 beta-galactoside alpha-2,3-sialyltransferase 4, ST3GalA.2, ST3Gal IV, ST3 β-galactoside α-2,3-sialyltransferase 4, ST-4, STZ, α-2,3 Sialyltransferase, β-galactosidase α-2,3-sialytransferase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat St3gal4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- beta-galactoside alpha-2,3-sialyltransferase
- glycosyltransferase family 29
- N-acetyllactosaminide alpha-2,3-sialyltransferase
- sialyltransferase
- enzyme
- protein binding
- monosialoganglioside sialyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- male pattern hair loss
- thrombocytopenia
- venous thromboembolism
- mumps
- coronary artery disease
- leprosy
- hypertension
- refractive error
- alopecia
- hyperlipidemia
role in cell
- expression in
- production in
- binding
- migration
- adhesion
- number
- function
- internalization by
- volume
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- Golgi membrane
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat St3gal4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- positive regulation of blood coagulation
- cognition
- glycoprotein biosynthetic process
- protein glycosylation
- glycolipid biosynthetic process
- oligosaccharide biosynthetic process
- keratan sulfate biosynthetic process
- O-glycan processing
- lipid glycosylation
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- membrane
- Golgi membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- sialyltransferase activity
- beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
- monosialoganglioside sialyltransferase activity
- N-acetyllactosaminide alpha-2,3-sialyltransferase activity