Alox15b Gene Summary [Rat]
Enables arachidonate 15-lipoxygenase activity. Involved in arachidonate metabolic process; hepoxilin biosynthetic process; and lipoxygenase pathway. Predicted to be located in several cellular components, including adherens junction; cytosol; and focal adhesion. Orthologous to human ALOX15B (arachidonate 15-lipoxygenase type B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alox15b |
| Official Name | arachidonate 15-lipoxygenase, type B [Source:RGD Symbol;Acc:628809] |
| Ensembl ID | ENSRNOG00000007778 |
| Bio databases IDs | |
| Aliases | arachidonate 15-lipoxygenase, type B |
| Synonyms | 15-LOX-2, 15-LOX-B, 8-LOX, 8S-LOX, Alox8, arachidonate 15-lipoxygenase type B, arachidonate 15-lipoxygenase, type B, arachidonate 8-lipoxygenase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alox15b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipoxygenase
- PLAT
- arachidonate 15-lipoxygenase
- calcium ion binding
- iron ion binding
- enzyme
- protein binding
- single donor 2 atom incorporation:oxygen oxidoreductase
- Lipoxygenase homology 2 (beta barrel) domain
Pathways
Biological processes and signaling networks where the Alox15b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- androgenic alopecia
- senile lentigo
- psoriasis
- prostatic hyperplasia
- venous thromboembolism
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
regulates
- reactive oxygen species
- lipid
- 15-hydroxyeicosatetraenoic acid
- 15 hydroxyeicosatrienoic acid
- linoleic acid
- arachidonic acid
- protectin D1
- Ly6a (includes others)
- 2-arachidonoylglycerol
- TP63
role in cell
- differentiation
- production in
- expression in
- growth
- apoptosis
- formation in
- proliferation
- cell cycle progression
- migration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- extranuclear space
- cytoskeleton
- cell borders
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- granules
- cytosol
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alox15b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of growth
- positive regulation of keratinocyte differentiation
- endocannabinoid signaling pathway
- positive regulation of peroxisome proliferator activated receptor signaling pathway
- negative regulation of cell proliferation
- lipid oxidation
- negative regulation of cell cycle
- linoleic acid metabolic process
- phospholipid metabolic process
- regulation of epithelial cell differentiation
- lipoxygenase pathway
- hepoxilin biosynthetic process
- apoptotic process
- lipid metabolic process
- lipoxin A4 biosynthetic process
- positive regulation of macrophage derived foam cell differentiation
- positive regulation of chemokine production
- prostate gland development
- arachidonic acid metabolic process
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- adherens junction
- extracellular vesicular exosome
- cytoskeleton
- focal adhesion
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding
- arachidonate 15-lipoxygenase activity
- calcium ion binding
- lipoxygenase activity
- lipid binding