Sp3 Gene Summary [Rat]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Part of protein-DNA complex and transcription repressor complex. Orthologous to human SP3 (Sp3 transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sp3 |
| Official Name | Sp3 transcription factor [Source:RGD Symbol;Acc:1583765] |
| Ensembl ID | ENSRNOG00000060479 |
| Bio databases IDs | |
| Aliases | Sp3 transcription factor |
| Synonyms | D130027J01RIK, LOC103691822, Sp3 transcription factor, SPR2, trans-acting transcription factor 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- transcription activation domain
- transcription factor binding
- chromatin binding
- protein binding
- Sp1 B domain
- sequence-specific DNA binding
- C2H2-type zinc ribbon
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
- transcription factor activity
Pathways
Biological processes and signaling networks where the Sp3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- preeclampsia
- cardiac hypertrophy
- hypertension
- Waldenström macroglobulinemia
- macrothrombocytopenia
- critical limb ischemia
- vitiligo
role in cell
- apoptosis
- cell death
- expression in
- induction in
- formation
- activation in
- binding in
- differentiation
- signaling in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- nuclear matrix fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear matrix
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- enucleate erythrocyte differentiation
- regulation of transcription, DNA-dependent
- embryonic skeletal system development
- positive regulation of transcription from RNA polymerase II promoter
- embryonic process involved in female pregnancy
- embryonic placenta development
- regulation of transcription from RNA polymerase II promoter
- definitive hemopoiesis
- T cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- megakaryocyte differentiation
- negative regulation of transcription, DNA-dependent
- ossification
- positive regulation of transcription, DNA-dependent
- natural killer cell differentiation
- myeloid progenitor cell differentiation
- liver development
- embryonic camera-type eye morphogenesis
- granulocyte differentiation
- trophectodermal cell differentiation
- monocyte differentiation
- lung development
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- transcriptional repressor complex
- protein-DNA complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity