Vrk2 Gene Summary [Rat]
Predicted to enable protein domain specific binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including DNA damage response; cellular response to oxidative stress; and regulation of signal transduction. Predicted to act upstream of or within protein autophosphorylation. Predicted to be located in endoplasmic reticulum membrane; mitochondrial membrane; and nuclear envelope. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human VRK2 (VRK serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vrk2 |
| Official Name | VRK serine/threonine kinase 2 [Source:RGD Symbol;Acc:1311585] |
| Ensembl ID | ENSRNOG00000007864 |
| Bio databases IDs | |
| Aliases | VRK serine/threonine kinase 2 |
| Synonyms | 2810003O05Rik, LOC101927261, vaccinia related kinase 2, VRK serine/threonine kinase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vrk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- protein kinase
- protein kinase binding
- Protein Kinases, catalytic domain
- protein domain specific binding
- protein binding
Pathways
Biological processes and signaling networks where the Vrk2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- major depression
- prostate cancer
- neuroticism
- schizophrenia
- opioid-related disorder
- depressive disorder
- generalized epilepsy
- gastric carcinoma
- gastric epithelial cancer
role in cell
- phosphorylation in
- expression in
- growth
- activation in
- binding in
- transcription in
- invasion
- tumorigenicity
- response by
- sphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- mitochondrial membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vrk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- signal transduction
- regulation of interleukin-1-mediated signaling pathway
- protein autophosphorylation
- cellular response to oxidative stress
- peptidyl-serine phosphorylation
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nucleus
- mitochondrial membrane
- cytoplasm
- macromolecular complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein domain specific binding
- protein binding
- protein serine/threonine kinase activity