Faf2 Gene Summary [Rat]
Predicted to enable several functions, including enzyme binding activity; lipase inhibitor activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; retrograde protein transport, ER to cytosol; and stress granule disassembly. Predicted to act upstream of or within lipid droplet organization. Predicted to be located in lipid droplet. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human FAF2 (Fas associated factor family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Faf2 |
| Official Name | Fas associated factor family member 2 [Source:RGD Symbol;Acc:1306577] |
| Ensembl ID | ENSRNOG00000017607 |
| Bio databases IDs | |
| Aliases | Fas associated factor family member 2 |
| Synonyms | 2210404D11Rik, ETEA, Fas associated factor family member 2, mKIAA0887, RGD1306577, UBXD8, UBXN3B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Faf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ubiquitin protein ligase binding
- UBA-like domain
- Ubl1_cv_Nsp3_N-like
- enzyme inhibitor activity
- protein binding activity, bridging
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme binding
- ubiquitin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- alcoholic cirrhosis
- chronic musculoskeletal pain
- ototoxicity
role in cell
- expression in
- apoptosis
- binding in
- degradation in
- organization
- disassembly
- contact growth inhibition
- mitophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Faf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- stress granule disassembly
- retrograde protein transport, ER to cytosol
- lipid particle organization
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- lipid particle
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex
- endoplasmic reticulum
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- lipase binding
- protein binding
- ubiquitin protein ligase binding
- ubiquitin binding
- lipase inhibitor activity
- protein binding, bridging